EAN: 9789400752665

MOLECULAR ASPECTS OF IRON METABOLISM IN PATHOGE...

Iron plays a key role in biology as essential cofactor of numerous proteins. However  since it
is only slightly soluble its bioavailability can be readily compromised under aerobic
conditions. Moreover  due to its ability to catalyze the generation of free radicals  iron can
also be toxic. Thus  it doesn't surprise that living organisms have developed sophisticated
means for acquiring iron whilst tightly controlling the intracellular concentrations of this
metal in response to environmental conditions. Also  the critical role of iron has long been
acknowledged in host vertebrate-parasite relationships where both partners compete for the
acquisition of this essential element and activate complex signaling cascades to control their
iron homeostasis during infection. Following the great interest that the mechanisms regulating
the acquisition of iron and the control of iron homeostasis have generated among researchers
studying plant-pathogen and legume-rhizobia interactions  this book offers a comprehensive
analysis of irons' various roles in the plant-microbial associations. The introductory chapter
stresses the essentiality of iron in biological systems. The second chapter surveys the
abundance of information on iron's pivotal role in microbial plant pathogenesis and defence.
Finally  the third chapter reviews the advances in our understanding of iron metabolism in the
rhizobia  soil bacteria able to establish a symbiotic association with legumes and carry out
nitrogen fixation. Molecular Aspects of Iron Metabolism in Pathogenic and Symbiotic
Plant-Microbe Associations is a valuable resource to microbiologists  pathologists and
scientists interested in iron uptake and metabolism in microbial pathogenesis  rhizobia legume
associations  and plant physiology and immunity.

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