Molecular Dynamics Analyses of Prion Protein Structures - Jiapu Zhang Gebunden

Unlike bacteria and viruses which are based on DNA and RNA prions are unique as disease-causing agents since they are misfolded proteins. Prion diseases are called protein structural conformational diseases. This monograph is the book on molecular dynamics (MD) simulations nearly for all the known normal prion protein (PrPC) PDB entries in the Protein Data Bank (PDB) and associations. Pig is a species that is largely resistant to prions and chicken turtles frogs are species resisting prion infection too firstly this book will address all PrP strong immunity species (such as rabbits dog s horses water buffaloes pigs chicken turtles frogs) compared with high susceptibility species. Other PrP models and doppel models are also MD studied in this book.Secondly all the mutants of mouse PrP and human PrP are well studied by this book. Mouse mutations in the beta2- 2 loop and the C-terminal will bring clear structures with highly and clearly ordered loop structures. Human mutations will cause prion diseases such as Creutzfeldt-Jakob diseases (CJDs) Gerstmann-Sträussler-Scheinker (GSS) syndrome fatal familial insomnia (FFI) etc. Deep MD analyses of mouse and human mutants are done in this book.Thirdly PrP binding with antibodies compounds etc. is well MD studied in this book. The informatics of potential antiprion drugs known will be revealed. Lastly cross-beta structure PrP peptides are well studied. This book is ideal for practical computing staff in the fields of computational physics computational biology computational chemistry biomedicine bioinformatics cheminformatics materials applied mathematics and theoretical physics information technology operations research biostatistics etc. As an accessible introduction to these fields this book is also ideal as a teaching material for students.