EAN: 9789811088148

MOLECULAR DYNAMICS ANALYSES OF PRION PROTEIN ST...

Unlike bacteria and viruses  which are based on DNA and RNA  prions are unique as
disease-causing agents since they are misfolded proteins. Prion diseases are called protein
structural conformational diseases. This monograph is the book on molecular dynamics (MD)
simulations nearly for all the known normal prion protein (PrPC) PDB entries in the Protein
Data Bank (PDB) and associations. Pig is a species that is largely resistant to prions  and
chicken  turtles  frogs are species resisting prion infection too  firstly  this book will
address all PrP strong immunity species (such as rabbits  dogs  horses  water buffaloes  pigs 
chicken  turtles  frogs)  compared with high susceptibility species. Other PrP models and
doppel models are also MD studied in this book.Secondly  all the mutants of mouse PrP and human
PrP are well studied by this book. Mouse mutations in the beta2- 2 loop and the C-terminal will
bring clear structures with highly and clearly ordered loop structures. Human mutations will
cause prion diseases such as Creutzfeldt-Jakob diseases (CJDs)  Gerstmann-Sträussler-Scheinker
(GSS) syndrome  fatal familial insomnia (FFI)  etc. Deep MD analyses of mouse and human mutants
are done in this book.Thirdly  PrP binding with antibodies compounds etc. is well MD studied in
this book. The informatics of potential antiprion drugs known will be revealed. Lastly 
cross-beta structure PrP peptides are well studied. This book is ideal for practical computing
staff in the fields of computational physics  computational biology  computational chemistry 
biomedicine  bioinformatics  cheminformatics  materials  applied mathematics and theoretical
physics  information technology  operations research  biostatistics  etc. As an accessible
introduction to these fields  this book is also ideal as a teaching material for students.

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