This book comprehensively reviews the state-of-the-art strategies developed for protein-protein
interaction (PPI) inhibitors and highlights the success stories in new drug discovery and
development. Consisting of two parts with twelve chapters it demonstrates the design
strategies and case studies of small molecule PPI inhibitors. The first part discusses various
discovery strategies for small molecule PPI inhibitors such as high throughput screening hot
spot-based design computational approaches and fragment-based design. The second part
presents recent advances in small molecule inhibitors focusing on clinical candidates and new
PPI targets. This book has broad appeal and is of significant interest to the pharmaceutical
science and medicinal chemistry communities.
