EAN: 9789811322174

INSIGHTS INTO HUMAN NEURODEGENERATION LESSONS L...

This book is aimed at generating an updated reservoir of scientific endeavors undertaken to
unravel the complicated yet intriguing topic of neurodegeneration. Scientists from Europe  USA
and India who are experts in the field of neurodegenerative diseases have contributed to this
book. This book will help readers gain insight into the recent knowledge obtained from
Drosophila model  in understanding the molecular mechanisms underlying neurodegenerative
disorders and also unravel novel scopes for therapeutic interventions. Different methodologies
available to create humanized fly models that faithfully reflects the pathogenicities
associated with particular disorders have been described here. It also includes information on
the exciting area of neural stem cells. A brief discussion on neurofibrillary tangles  precedes
the elaborate description of lessons learnt from Drosophila about Alzheimer's  Parkinson's 
Spinomuscular Atrophy  Huntington's diseases  RNA expansion disorders and Hereditary Spastic
Paraplegia. We have concluded the book with the use of Drosophila for identifying
pharmacological therapies for neurodegenerative disorders. The wide range of topics covered
here will not only be relevant for beginners who are new to the concept of the extensive
utility of Drosophila as a model to study human disorders  but will also be an important
contribution to the scientific community  with an insight into the paradigm shift in our
understanding of neurodegenerative disorders. Completed with informative tables and
communicative illustrations this book will keep the readers glued and intrigued. We have
comprehensively anthologized the lessons learnt on neurodegeneration from Drosophila and have
thus provided an insight into the multidimensional aspects of pathogenicities of majority of
the neurodegenerative disorders.

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