EAN: 9789811358760

MOLECULAR DIAGNOSTICS IN CANCER PATIENTS GEBUNDEN

This book aims to bring together a broad variety of examples of the role of pharmacogenomics in
current drug development  uncovering dynamic concentration-dependent drug responses on
biological systems to understand pharmacodynamics responses in human cancer where genetic
lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes
methods and protocols applied in molecular diagnostics. It offers pathologists and researchers
providing molecular diagnostic services an array of the most recent and readily accessible
reference to compare methods and techniques. Highlights include the molecular diagnosis of
genetic aberrations by quantitative polymerase reaction (qPCR)  sequence-specific
oligonucleotide arrays  next-generation sequencing (NGS)  CGH arrays-and methodologies directed
at the detection of epigenetic events  high-throughput nucleic acid and protein arrays  direct
sequencing and FISH-based methodologies  currently used in the diagnosis of solid tumors. The
book also includes an innovative line of treatment in relation to the molecular prognosis 
diagnosis and pharmacogenomics in the actual practice of clinical findings at molecular levels.
The book covers the applications of numerous genetic testing methodologies  in approximately
the chronological order of discovery and high-throughput diagnosis using advanced genomic
approaches to identify such genes  in the search for novel drug targets and or key determinants
of drug reactions. It also promotes a wider understanding of molecular diagnostics among
physicians  medical students  and scientists in academics  industry and corporate world.

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