This is an open access book. This book first of all introduces the new unveiled
Guangdong-Macao Intensive Cooperation Zone with details as a special mode of the regional
collaborative development that is committed to be mutually beneficial to both sides with
different political and economic systems. China's central authorities have recently issued a
masterplan for constructing the Guangdong-Macao Intensive Cooperation Zone at Hengqin Island in
September 2021. As China's first and last European colony and one of China's two special
administrative regions (SARs) Macao has developed the gambling industry seven times larger
than that of Las Vegas. However the problem of the homogeneous industrial structure and the
urgent need to promote sustainable economic growth by regional cooperation have been important
theoretical and practical issues discussed by scholars and policy-makers. The Guangdong-Macao
Intensive Cooperation Zone (ICZ) is managed under special customs supervision between two
boarder lines and expected to diversify Macao's economy. Then this book dissects the theory of
regional synergistic development and its applications in a number of international comparative
and cross-interdisciplinary case studies worldwide. Finally from the perspective of land use
transportation connection and social service this book thoroughly explores the challenges and
strategies to implement the new cooperation model within the framework of one country two
systems two customs and two currencies to achieve a win-win situation using updated
first-hand data collected by literature review case study field survey spatial analysis and
interview.