Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and
the development validation and implementation of the most common assays seen in clinical
labs. It provides readers with practical examples for assay development and experimental
design for validation to meet CLIA requirements appropriate interference testing measuring
validation of ion suppression matrix effects and quality control. These tools offer guidance
on what type of instrumentation is optimal for each assay what options are available and the
pros and cons of each. Readers will find a full set of tools that are either directly related
to the assay they want to adopt or for an analogous assay they could use as an example. Written
by expert users of the most common assays found in a clinical laboratory (clinical chemists
toxicologists and clinical pathologists practicing mass spectrometry) the book lays out how
experts in the field have chosen their mass spectrometers purchased installed validated and
brought them on line for routine testing. The early chapters of the book covers what the
practitioners have learned from years of experience the challenges they have faced and their
recommendations on how to build and validate assays to avoid problems. These chapters also
include recommendations for maintaining continuity of quality in testing. The later parts of
the book focuses on specific types of assays (therapeutic drugs Vitamin D hormones etc.).
Each chapter in this section has been written by an expert practitioner of an assay that is
currently running in his or her clinical lab.
