Although more than 10 new antiepileptic drugs have been developed in the past decade epilepsy
remains resistant to drug therapy in about one third of patients many of whom struggle with
the disease their entire lives. Managing these patients is a challenge and requires a
structured multidisciplinary approach. The book includes chapters on all issues related to
pharmacoresistance in epilepsy and describes recent developments in the pathogenesis and
treatment of this disorder. It addresses abnormalities in inhibitory mechanisms
epilepsy-related changes to the immune system development of pharmacoresistance caused by
chronic exposure to antiepileptic drugs and novel therapeutic strategies for preventing or
slowing down the progression of the disease. Clinicians and basic scientists alike will find
up-to-date information on the development of pharmacoesistance as well as reviews of
mechanisms associated with epilepsy that may help them consider novel strategies for preventing
the development of pharmacoresistance in the first place. The book also features information on
new therapeutic strategies for control of epilepsy such as transcutaneous electrical
stimulation and virtual screening of new antiepileptic drugs. Pharmacoresistance in Epilepsy:
From Genes and Molecules to Promising Therapies is useful to anyone working in the field
whether they¿re studying epilepsy in the lab or treating it in a doctor¿s office.¿
