Leading basic and clinical investigators from around the world summarize the most recent
research on the molecular and cellular origins of lupus. Their cutting-edge articles review the
mechanisms underlying abnormal immunity and introduce the powerful new concept that a disorder
of multiple genes underlies the abnormal immune response leading directly to the development
of lupus. This pathophysiology is shown to involve a wide variety of cell types including T
cells B cells natural killer cells macrophages monocytes and endothelial cells. Over time
the resulting long-term inflammation causes irreversible cell destruction and ultimately
organ failure. Lupus: Molecular and Cellular Pathogenesis is a masterful new synthesis of all
the new knowledge emerging today about lupus. Its new perspectives will sharpen the focus of
research and ultimately lead to better and more effective treatment.
