This volume offers a comprehensive guide on the theory and practice of amorphous solid
dispersions (ASD) for handling challenges associated with poorly soluble drugs. In twenty-three
inclusive chapters the book examines thermodynamics and kinetics of the amorphous state and
amorphous solid dispersions ASD technologies excipients for stabilizing amorphous solid
dispersions such as polymers and ASD manufacturing technologies including spray drying hot
melt extrusion fluid bed layering and solvent-controlled micro-precipitation technology (MBP).
Each technology is illustrated by specific case studies. In addition dedicated sections cover
analytical tools and technologies for characterization of amorphous solid dispersions the
prediction of long-term stability and the development of suitable dissolution methods and
regulatory aspects. The book also highlights future technologies on the horizon such as
supercritical fluid processing mesoporous silica KinetiSol® and the use of non-salt-forming
organic acids and amino acids for the stabilization of amorphous systems.Amorphous Solid
Dispersions: Theory and Practice is a valuable reference to pharmaceutical scientists
interested in developing bioavailable and therapeutically effective formulations of poorly
soluble molecules in order to advance these technologies and develop better medicines for the
future.
