Receptor Tyrosine Kinase: Structure Functions and Role in Human Disease for the first time
systematically covers the shared structural and functional features of the RTK family. Receptor
Tyrosine Kinases (RTKs) play critical roles in embryogenesis normal physiology and several
diseases. And over the last decade they have become the Number 1 targets of cancer drugs. To be
able to conduct fundamental research or to attempt to develop pharmacological agents able to
enhance or intercept them it is essential first to understand the evolutionary origin of the
58 RTKs and their roles in invertebrates and in humans as well as downstream signaling
pathways. The assembly of chapters is written by experts and underscores commonalities between
and among the RTKs. It is an ideal companion volume to The Receptor Tyrosine Kinase: Families
and Subfamilies which proceeds family by family through all of the specific subfamilies of
RTKs along with their unique landmarks.
