This detailed volume provides an overview of recent techniques employed in the field of G
protein-coupled receptors (GPCRs) to screen for new drugs and to derive information about their
receptor structure dynamics and function for the purpose of developing improved therapeutics.
Owing to remarkable recent advances in the structural biophysical and biochemical analyses of
these receptors as well as a growing body of evidence hinting at the possible relevance of
allosteric modulators biased agonists and oligomer-selective ligands as improved therapeutic
agents drug discovery for GPCRs has recently taken a completely new direction. For this book
expert contributors have shared their protocols and views on the impact of these methodologies
on modern drug discovery. Written for the highly successful Methods in Molecular Biology series
chapters include introductions to their respective topics lists of the necessary materials and
reagents step-by-step readily reproduciblelaboratory protocols and tips on troubleshooting
and avoiding known pitfalls.Practical and fully updated G Protein-Coupled Receptors in Drug
Discovery: Methods and Protocols Second Edition serves as an ideal guide for a diverse
audience from structural and molecular biologists to pharmacologists and drug designers who
wish to explore this extensive class of key drug targets.
