This comprehensive volume explores human genetic engineering its pre-clinical and clinical
applications current developments and as treatment for hereditary diseases. It presents and
evaluates the most recent advances in the understanding of mammalian host DNA repair mechanisms
such as double-strand break induced gene targeting and mutagenesis the development of
zinc-finger nucleases genome editing for neuromuscular diseases phase integrases triplex
forming oligonucleotides and peptide nucleic acids aptamer-guided gene targeting AAV gene
editing via DSB repair engineered nucleases and trinucleotide repeat diseases and creation of
HIV-resistant cells. The expertly authored chapters contextualize current developments within
the history of genome editing while also discussing the current and potential safety concerns
of this rapidly growing field. Genome Editing: The Next Step in Gene Therapy the latest volume
in the American Society of Gene and Cell Therapy series deftly illuminates the potential of
genetic engineering technology to eradicate today's deadliest and most prolific diseases. It is
ideal reading for clinicians and researchers in genetics and immunology.
