This second edition provides up-to-date chapters and new chapters focusing on the most recent
advances in the field of drug safety evaluation. Divided into seven parts chapters detail
specific aspects related to the experimental design of preclinical studies conducted to support
the safety of pediatric and combination drugs necropsy and histopathology evaluation mass
spectrometry imaging genetic toxicology protocols including the Pig-a mutation assay safety
pharmacology methods such as automatization of patch-clamp procedures target safety assessment
for investigative toxicology screening assays for developmental toxicology and methods to
characterize novel translational safety biomarkers like microRNAs. Written in the highly
successful Methods in Molecular Biology series format chapters include introductions to their
respective topics lists of the necessary materials and reagents step-by-step readily
reproducible laboratory protocols and tips on troubleshooting to avoid known
pitfalls.Authoritative and practical Drug Safety Evaluation: Methods and Protocols Second
Edition aims to ensure successful results in the further study of this vital field.
