This volume presents forty-two methods and protocols to analyze diverse aspects of genome
instability. Chapters detail mutagenesis and repair methods to quantify and analyze the
properties of DNA double-strand breaks profile replication replication proteins
strand-specifically genome instability fluorescence microscopic techniques and genomic and
proteomic approaches. Written in the highly successful Methods in Molecular Biology series
format chapters include introductions to their respective topics lists of the necessary
materials and reagents step-by-step readily reproducible laboratory protocols and tips on
troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge Genome
Instability: Methods and Protocols aims to provide a comprehensive resource for the discovery
and analysis of the proteins and pathways that are critical for stable maintenance of the
genome.
