This detailed book gathers a broad collection of experimental approaches to assist researchers
in setting up different methods to investigate protein conformational disorders. Beginning with
a section on assays focusing on biophysical approaches to study protein (mis)folding the
volume continues with sections on cellular and proteostasis assays as well as assays for
protein folding correction and recovery combining methods such as thermal shift assays in
silico improvement of protein solubility and compound screening an important area of research
as it may open avenues for therapeutic strategies. Written for the highly successful Methods in
Molecular Biology series chapters include introductions to their respective topics lists of
the necessary materials and reagents step-by-step readily reproducible laboratory protocols
and tips for troubleshooting and avoiding known pitfalls. Authoritative and practical Protein
Misfolding Diseases: Methods and Protocols serves asan ideal guide for researchers seeking to
advance our knowledge of protein conformational disorders.
