This book covers strategies to improve cell permeability intestinal permeability and
metabolic stability which are the typical liabilities associated with cyclic peptides to
enhance protein-protein recognition and to build upon nature's cyclic peptides and
macrocycles. Chapters also cover key peptide screening and display strategies as well as
important synthetic approaches towards cyclic and helical peptides. Cyclic peptides have become
of significant importance as chemical tools in biology and drug discovery since this class of
chemicals has become a credible alternative source of new drug leads on par with traditional
small molecules. As a part of the Methods in Molecular Biology series this collection includes
the kind of detail and implementation advice to aid researchers in the field. Authoritative and
cutting-edge Cyclic Peptide Design serves as a critical resource and go-to reference for
researchers within the pharmaceutical industry as well as scientists and students in the
bioorganic medicinal and natural product chemistry fields.
