This collection of articles on oxidative stress in clinical practice surveys essential current
research in what is a rapidly evolving field. As well as giving the reader a mechanistic
overview of how oxidative stress affects cardiovascular disease it analyzes the potential of a
number of therapeutic options that target these pathways. Understanding the complexity of the
cellular redox system could lead to the development of better targeted interventions that
facilitate patient recovery. Even as large-scale clinical trials of so-called 'simple'
antioxidant approaches such as vitamins C and E show that significant benefits for
cardiovascular patients remain elusive Studies on Cardiovascular Disorders demonstrates that
such approaches are too simplistic. Beginning with a summary of redox signaling models that
could induce the progression of redox-associated cardiovascular disorders the volume moves on
to examine redox-mediated protein modification under physiological and pathophysiological
conditions. It provides an outline of the signaling pathways in cardiovascular development
during embryogenesis and what impact these might have in the differentiation process of
resident cardiac and blastocyst derived stem cells. Further chapters detail our current
knowledge of the influence the sensory nervous system exerts on the cardiovascular system and
the paradoxical role of mitochondria-derived ROS in cardiac protection. In all almost 30
contributions cover issues as diverse as the antioxidant properties of statins in the heart and
the oxidative risk factors for cardiovascular disease in women. A range of medical
practitioners will find the contents of Studies on Cardiovascular Disorders provides
illuminating insight into the Janus-faced role of ROS in the cardiovascular system.
