Features that characterize the aging process include the gradual accumulation of cell damage
after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to
the accretion of lesions the intrinsic levels of pro-oxidant and aberrant immune responses are
elevated with age. These adverse events are often further enhanced by the chronic and slow
progressing diseases that characterize the senescent brain and cardiovascular system. The
incidence of some disorders such as Alzheimer's disease and vascular diseases are sufficiently
prevalent in the extreme elderly that these disorders can arguably be considered normal. Aging
and Aging-Related Disorders examines the interface between normal and pathological aging and
illustrates how this border can sometimes be diffuse. It explores and illustrates the processes
underlying the means by which aging becomes increasingly associated with inappropriate levels
of free radical activity and how this can serve as a platform for the progression of
age-related diseases. The book provides chapters that examine the interactive relationship
between systems in the body that can enhance or sometimes even limit cellular longevity. In
addition specific redox mechanisms in cells are discussed. Another important aspect for aging
discussed here is the close relationship between the systems of the body and exposure to
environmental influences of oxidative stress that can affect both cellular senescence and a
cell's nuclear DNA. What may be even more interesting to note is that these external stressors
are not simply confined to illnesses usually associated with aging but can be evident in
maturing and young individuals. A broad range of internationally recognized experts have
contributed to this book. Their aim is to successfully highlight emerging knowledge and therapy
for the understanding of the basis and development of aging-related disorders.
