EAN: 9781617790119

DRUG DESIGN AND DISCOVERY GEBUNDEN

Research in the pharmaceutical sciences and medicinal chemistry has taken an important new
direction in the past two decades with a focus on large molecules  especially peptides and
proteins  as well as DNA therapeutics. In Drug Design and Discovery: Methods and Protocols 
leading experts provide an in-depth view of key protocols that are commonly used in drug
discovery laboratories. Covering both classic and cutting-edge techniques  this volume explores
computational docking  quantitative structure-activity relationship (QSAR)  peptide synthesis 
labeling of peptides and proteins with fluorescent labels  DNA-microarray  zebrafish model for
drug screening  and other analytical screening and biological assays that are routinely used
during the drug discovery process. Written in the highly successful Methods in Molecular
Biology(TM) series format  chapters include introductions to their respective topics  lists of
the necessary materials  step-by-step  readily reproducible laboratory protocols  and tips on
troubleshooting and avoiding known pitfalls. Thorough and accessible  Drug Design and
Discovery: Methods and Protocols serve as a vital laboratory reference for pharmaceutical
chemists  medicinal chemists  and pharmacologists as well as for molecular biologists.

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