Due to the complexity of the mitochondrial system and the myriad genes involved in their
function the clinical manifestations of mitochondrial diseases are remarkably variable and
heterogeneous. The laboratory and clinical methodologies used to evaluate dysfunction may vary
widely and thusly a systematic presentation of the numerous protocols that are applied to the
assessment of these clinically and genetically heterogeneous disorders has proven to be
essential. Mitochondrial Disorders: Biochemical and Molecular Analysis strives to fill this
need with a collection of key protocols provided by leading experts in the field. Beginning
with overviews of complexity of mitochondrial and nuclear genome disorders the book continues
with a section devoted to current biochemical protocols and a part focused on the DNA-based
approaches used to identify molecular defects. Written in the highly successful Methods in
Molecular Biology(TM) series format chapters contain introductions to their respective topics
lists of the necessary materials and reagents step-by-step readily reproducible laboratory
protocols and tips on troubleshooting and avoiding known pitfalls. Detailed and authoritative
Mitochondrial Disorders: Biochemical and Molecular Analysis serves as a vital guide to
researchers seeking to understand this incredibly complicated type of breakdown in cellular
biology.
