Entities leak into the human realm and enter human minds. Two of the victims are Dr. Watson and
leader of the cult Prof. Henry Fitzgerald--who seeks to use human sacrifice to open the door
to the Old Ones. As violence erupts in London Holmes secludes himself in the Diogenes Club
developing an antidote to counter the neural psychoses. As Moriarty uses the drug to amass an
army of addicts Holmes discovers a link to a town in America. Innsmouth.