This book constitutes the refereed joint proceedings of the First International Workshop on
Data Driven Treatment Response Assessment DATRA 2018 and the Third International Workshop on
Preterm Perinatal and Paediatric Image Analysis PIPPI 2018 held in conjunction with the 21st
International Conference on Medical Imaging and Computer-Assisted Intervention MICCAI 2018 in
Granada Spain in September 2018. The 5 full papers presented at DATRA 2018 and the 12 full
papers presented at PIPPI 2018 were carefully reviewed and selected. The DATRA papers cover a
wide range of exploring pattern recognition technologies for tackling clinical issues related
to the follow-up analysis of medical data with focus on malignancy progression analysis
computer-aided models of treatment response and anomaly detection in recovery feedback.The
PIPPI papers cover topics of advanced image analysis approaches focused on the analysis of
growth and development in the fetal infant and paediatric period.