This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency in
characterizing residual viral reservoirs and in developing targeted interventions to reduce
HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular
mechanisms that govern and regulate HIV-1 transcription and latency assays and technical
approaches to quantify viral reservoirs in humans and animal models the complex interchange
between viral reservoirs and the host immune system computational strategies to model viral
reservoir dynamics and the development of therapeutic approaches that target viral reservoir
cells. With contributions from an interdisciplinary group of investigators that cover a broad
spectrum of subjects from molecular virology to proof-of-principle clinical trials this book
is a valuable resource for basic scientists translational investigators infectious-disease
physicians individuals living with HIV AIDS and the general public.
