This book constitutes the thoroughly refereed post-conference proceedings of the 12th
International Conference on Learning and Intelligent Optimization LION 12 held in Kalamata
Greece in June 2018. The 28 full papers and 12 short papers presented have been carefully
reviewed and selected from 62 submissions. The papers explore the advanced research
developments in such interconnected fields as mathematical programming global optimization
machine learning and artificial intelligence. Special focus is given to advanced ideas
technologies methods and applications in optimization and machine learning.