This handbook is the first comprehensive book of its kind reviewing the clinically relevant
current status of tissue kallikrein and kallikrein-related peptidases research. Since several
members of the KLK family are key players in (patho-)physiological processes structural
functional and regulatory studies are under way to develop new strategies to prevent and treat
disorders to which individual members of the KLK protease family contribute significantly. The
goal of this book is to inform clinicians physician scientists and researchers about the
prominent role of the multifaceted and interactive KLK system in normal physiology and
pathological organ function.