EAN: 9783110515022

MACROLIDES - BILJANA ARSIC PREDRAG NOVAK GORAN ...

Macrolide antibiotics represent a class of natural macrocyclic products  one of the most
clinically important antibiotics. Unfortunately  the production and development of new
macrolide antibiotics are not represented enough in the pharmaceutical industry today. The
intention of the book is therefore not only to be a teaching tool for students and experts  but
also to draw the attention of the general public to this extremely useful  cheap and relatively
unharmful effective anti-macrobials  and potential anti-malarials. The authors introduce the
different classes of macrolides and their derivatives  principles of their biological activity
their structure and interactions with biological targets as well as synthetic methods to
produce new macrolide antibiotics of similar or improved properties. Special emphasis was put
on conjugates of macrolides with nucleobases or nucleosides with numerous applications  among
them the most important remains the attempt to overcome bacterial resistance.

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