The discovery of proton pump inhibitors (PPIs) and their development over the years has
dramatically changed the management of acid-related diseases. Today the therapeutic domain of
PPIs ranges from relief of symptoms to cure of mucosal lesions in the upper gastrointestinal
tract. PPIs are among the most widely sold drugs in the world and are now even available as
over-the-counter medication. This publication presents the experience of the last 25 years
during which PPIs have become of enormous value in gastroenterology. The authors provide an
update on a variety of subjects starting with an introduction to the discovery and development
of PPIs. This is followed by chapters on pharmacokinetics pharmacodynamics and
pharmacogenetics gastroesophageal reflux disease gastroprotection Helicobacter pylori
eradication treatment peptic ulcer disease functional dyspepsia acid suppression in exocrine
pancreatic insufficiency and gastrointestinal and systemic side effects. Readers who are
interested in a current overview of PPIs and their various applications will find this book of
great value.
