The orexin system discovered in 1998 has emerged as a crucial player in regulating the sleep
and wake balance inside our brain. This discovery has sparked a burst of novel and dynamic
research on the physiology and pathology of sleep. The Orexin System: Basic Science and Role in
Sleep Pathology honors this research and the authors share their ideas and perspectives on the
novel developments within the field. The book examines the intricate role of the orexin system
in regulating sleep and wake and its interaction with other wake-regulating systems. The
orexin system is dissected at the cellular and molecular level to explore the diversity of the
orexin-producing neurons their projections and their signaling pathways. Additionally the
book discusses the diseases which are associated with a dysfunctional orexin system such as
narcolepsy insomnia substance abuse and Alzheimer's disease and explores the new potential
therapeutic applications derived from the burst of research around this fascinating system.
This publication is essential reading for neurobiologists neurologists psychopharmacologists
sleep researchers and other researchers and clinical scientists interested in sleep sleep
research insomnia and medicine in general.
