Chronic lymphocytic leukemia (CLL) is the most diagnosed leukemia in the Western world
accounting for approximately 25% of all new leukemia diagnoses. In recent years remarkable
progress has been made in our understanding of both the pathophysiology and genetics of CLL.
While the disease generally affects older adults and initially follows an indolent course
cytogenetic and molecular profiling have helped to predict clinical outcomes. Greater
prognostication alongside the development of an increasing armamentarium of novel targeted
therapies has enabled us to provide more personalized management options for patients. 'Fast
Facts: Chronic Lymphocytic Leukemia' covers the epidemiology etiology diagnosis and staging
of the disease and the molecular and genetic aspects that underpin treatment and prognosis. It
provides a concise overview of treatment options in both the front-line and relapsed
refractory settings with particular focus on the novel targeted agents that have overcome many
adverse prognostic factors improving overall survival. Table of Contents: -Epidemiology and
etiology -Molecular biology and genetics -Diagnosis staging and prognosis -Management
-Research directions
