Myelofibrosis is a myeloproliferative neoplasm that has markedly heterogeneous features. The
clinical phenotype can range from initial indolent presentation which may be stable for many
years through to marked cytopenias debilitating constitutional symptoms massive splenomegaly
and an inherent risk of leukemic transformation. Despite many advances regarding molecular
classification prognostication models and rapeutic options over the last few decades
allogeneic stem cell transplantation remains the only curative option yet is suitable only for
a minority of patients. 'Fast Facts: Myelofibrosis' is written for health professionals by two
leading experts in the field and provides up-to-date guidance on its accurate diagnosis risk
stratification and management. It also provides key insights into the molecular biology
underpinning the disease. This concise handbook is an indispensable read for anyone wanting to
get up to speed with best practice in the diagnosis and care of people with myelofibrosis.
Table of Contents: -Presentation classification and epidemiology -Molecular biology and
pathogenesis -Clinical assessment and diagnosis -Prognostic models -Treatment approaches
-Allogeneic stem cell transplantation -Management of blast-phase myelofibrosis -Therapies in
development
