Although sickle cell anemia was the first molecular disease to be identified its complex and
fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin
gene incurs numerous molecular and cellular mechanisms that contribute to the plethora of
symptoms associated with the disease. Our knowledge regarding sickle cell disease mechanisms
while still not complete has broadened considerably over the last decades. Sickle Cell Anemia:
From Basic Science to Clinical Practice aims to provide an update on our current understanding
of the disease's pathophysiology and use this information as a basis to discuss its
manifestations in childhood and adulthood. Current therapies and prospects for the development
of new approaches for the management of the disease are also covered.
