Together the volumes in this series present all of the data needed at various length scales
for a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and
ventilatory systems especially multiscale modeling and coupled simulations. The cardiovascular
and respiratory systems are tightly coupled as their primary function is to supply oxygen to
and remove carbon dioxide from the body's cells. Because physiological conduits have deformable
and reactive walls macroscopic flow behavior and prediction must be coupled to nano- and
microscopic events in a corrector scheme of regulated mechanism. Therefore investigation of
flows of blood and air in anatomical conduits requires an understanding of the biology
chemistry and physics of these systems together with the mathematical tools to describe their
functioning in quantitative terms.The present volume focuses on macroscopic aspects of the
cardiovascular and respiratory systems in pathological conditions i.e. diseases of the
cardiac pump blood vessels and airways as well as their treatments. Only diseases that have
a mechanical origin or are associated with mechanical disorders are covered. Local flow
disturbances can trigger pathophysiological processes or conversely result from diseases of
conduit walls or their environment. The ability to model these phenomena is essential to the
development and manufacturing of medical devices which incorporate a stage of numerical tests
in addition to experimental procedures.
