As indicated by its title this monograph deals chiefly with morphologically recognizable
deviations from the normal anatomical condition of the human CNS. The AD-associated pathology
is illustrated from its beginnings (sometimes even in childhood) to its final form which is
reached late in life. The AD process commences much earlier than the clinically recognizable
phase of the disorder and its timeline includes an extended preclinical phase. The further the
pendulum swings away from the symptomatic final stages towards the early pathology the more
obvious the lesions become although from a standpoint of severity they are more unremarkable
and thus frequently overlooked during routine neuropathological assessment. For this reason
the authors deal with the hallmark lesions in the early phases of the AD process in
considerable detail
