Reviewing exhaustively the current state of the art of tissue engineering strategies for
regenerating bones and joints through the use of biomaterials growth factors and stem cells
along with an investigation of the interactions between biomaterials bone cells growth
factors and added stem cells and how together skeletal tissues can be optimised this book
serves to highlight the importance of biomaterials composition surface topography
architectural and mechanical properties in providing support for tissue regeneration.Maximizing
reader insights into the importance of the interplay of these attributes with bone cells
(osteoblasts osteocytes and osteoclasts) and cartilage cells (chondrocytes) this book also
provides a detailed reference as to how key signalling pathways are activated. The contribution
of growth factors to drive tissue regeneration and stem cell recruitment is discussed along
with a review the potential and challenges of adult or embryonic mesenchymal stem cells to
further enhance the formation of new bone and cartilage tissues.This book serves to demonstrate
the interconnectedness of biomaterials bone cartilage cells growth factors and stem cells in
determining the regenerative process and thus the clinical outcome.
