Novel topics compiled in this one-of-a-kind volume provide tantalizing hints for clinical
application through future translational research. Only recently have we come to ask what role
the male might play in pregnancy loss and embryo implantation failure beyond contributing an
abnormal set of paternal chromosomes at fertilization. This volume explores the recent evidence
that these conditions might also be related to the transmission of previously unrecognized
chromosomal micro-deletions and duplications or via the epigenetic dysregulation of early
embryonic gene function by spermatozoal microRNAs or alterations in sperm DNA methylation
patterning or by DNA damage secondary to either reactive oxygen species or environmental
toxicants. In addition the composition of seminal plasma has been found to be highly complex
containing many factors that play important roles in altering the uterine environment and the
female immune system permissive of embryo implantation and trophectoderm outgrowth leading to
successful pregnancy. Coverage includes an examination of both spermatozoa and seminal fluid
component factors.
