This book constitutes the refereed proceedings of the 15th Conference on Artificial
Intelligence in Medicine AIME 2015 held in Pavia Italy in June 2015. The 19 revised full
and 24 short papers presented were carefully reviewed and selected from 99 submissions. The
papers are organized in the following topical sections: process mining and phenotyping data
mining and machine learning temporal data mining uncertainty and Bayesian networks text
mining prediction in clinical practice and knowledge representation and guidelines.