This book is a rich source of information on biomarkers applicable to the pathology of
neoplastic disorders of the brain. Thorough descriptions are provided of the techniques
currently available for clinical and experimental evaluation of biomarkers in brain neoplasms
including in situ hybridization array-based methods methylation profiling next-generation
sequencing and practical gene panels. Incorporation of multiple biomarkers in the development
of molecular subgroups with biologic and therapeutic relevance is also discussed. A section on
biobanking covers the equally important topic of optimal preservation of tissue and includes
consideration of ethical considerations raised by the use of tissue obtained in clinical
settings. The closing section discusses the major categories of neoplastic disorders involving
the nervous system with emphasis on diagnostic prognostic and predictive biomarkers used in
the pathologic evaluation of different types of brain tumor.
