This book provides the first comprehensive overview of a new scientific discipline termed
Geroscience. Geroscience examines the molecular and cellular mechanisms that might explain why
aging is the main risk factor for most chronic diseases affecting the elderly population. Over
the past few decades researchers have made impressive progress in understanding the genetics
biology and physiology of aging. This book presents vital research that can help readers to
better understand how aging is a critical malleable risk factor in most chronic diseases which
in turn could lead to interventions that can help increase a healthy lifespan or
¿healthspan.¿ The book begins with an analysis of the Geroscience hypothesis as well as the
epidemiological underpinnings that define aging as a candidate main risk factor for most
chronic diseases. Next each chapter focuses on one particular disease or group of diseases
with an emphasis on how basic molecular and cellular biology might explain why aging is a major
risk factor for it. Coverage in the book includes: cancer cardiovascular disease dementias
stroke Parkinson's and Alzheimer¿s diseases osteoporosis arthritis diabetes asthma
emphysema kidney disease vision impairment and AIDS HIV. It finishes with a chapter on pain
in the elderly and an overview of future steps needed to bring the newly acquired knowledge
into the clinic and the public at large.
