This book describes the most recent insights into heart failure and the role played by
autonomic nervous system pathophysiology in it discussing the therapeutic implications. While
current therapeutic approaches are able to control the effects of excessive adrenergic
activation in heart failure syndrome the underlying abnormalities of adrenergic control remain
unaltered and can still cause progression to unmanageable end-stage heart failure. New
therapeutic pathways are therefore being explored with a view to developing interventions that
can directly modulate adrenergic over-activity and restore a more appropriate balance in neural
control of the cardiovascular system. The book opens by examining current heart failure
therapies. Advances in our understanding of autonomic regulation dysregulation in heart failure
are then discussed in detail in the context of the search for more effective therapies. A
concluding section addresses the role of autonomic nervous system denervation in heart failure.
The authors are top scientists from leading research centers.
