This brief guide takes current clinical trial protocols totask and replaces them with a
contemporary framework for improvingnext-generation antidepressants and their underlying
science. Innovative modelsare based on a nuanced neurologically-informed understanding of
drugmechanisms and the component cognitive mood and behavioral aspects ofdepression. The book
reconceptualizes not only the clinical trial process butthe clinical concept of depression
itself as essential to bringingpharmaceutical research and development up to date boosting
efficiency andeffectiveness finding new molecules and reducing waste. Case studies and
areview of salient depression scales illustrate the potential benefits of suchwide-scale
change. Included in the coverage: Why now the need for a new clinical trials model for
antidepressants? Aims and basic requirements of clinical trials: conventional and
component-specific models. Methods for measuring the components and the profile of drug
actions: the multivantaged approach. Achieving the ideal clinical trial: an example of the
merged componential and established models. Prediction and shortening the clinical trial. The
video clinical trial. Clinical Trials ofAntidepressants will interest a varied audience
including clinicalinvestigators academic and pharmaceutical company scientists clinical
trialorganizations psychiatrists outpatient physicians psychotherapists
clinicalpsychologists psychology graduate students medical students and governmentagencies
such as the FDA.
