This book constitutes the refereed proceedings of the 16th International Conference on Software
Process Improvement and Capability Determination SPICE 2016 held in Dublin Ireland in June
2016. The 28 full papers presented together with 5 short papers were carefully reviewed and
selected from 52 submissions. The papers are organized in the following topical sections: SPI
in regulated and safety critical domains gamification and education issues in SPI SPI in
agile and small settings SPI and assessment SPI and project management concerns empirical
research case studies of SPI knowledge and human communications issues in SPI.