This comprehensive text provides a much-needed review of a disease that is currently garnering
the interest of molecular biologists translational scientists and clinicians. The volume
includes emerging developments in the molecular genetics of endometrial carcinoma. In addition
to covering the basic genetics of endometrial carcinoma chapters also cover a wide range of
signaling pathways implicated in endometrial carcinoma. A section of the book includes a number
of genetically engineered mouse models which contribute to understanding the role of various
genetic alterations in the development and progression of endometrial carcinoma. These models
also provide preclinical models for developing effective targeted therapeutic approaches.
Endometrial carcinoma is the most common malignancy of the female genital tract in the United
States and the number of cases continues to increase around the world. This book is a meant to
serve as a resource for a wide range of scientists frommolecular geneticists to signal
transduction biologists as well as to both clinicians and scientists interested in developing
targeted therapeutic approaches for women with endometrial carcinoma.
