This book constitutes the refereed proceedings of the First International Workshop on
Simulation and Synthesis in Medical Imaging held in conjunction with MICCAI 2016 in Athens
Greece in October 2016. The 17 revised full papers presented together in this book were
carefully reviewed and selected from 21 submissions. The contributions span the following broad
categories: fundamental methods for image-based biophysical modeling and image synthesis
biophysical and data-driven models of disease progression or organ development biophysical and
data-driven models of organ motion and deformation biophysical and data-driven models of image
formation and acquisition segmentation registration across or within modalities to aid the
learning of model parameters cross modality (PET MR PET CT CT MR etc.) image synthesis
simulation and synthesis from large-scale image databases automated techniques for quality
assessment of simulations and synthetic images as well as several applications of image
synthesis and simulation in medical imaging such as image registration and segmentation image
denoising and information fusion image reconstruction from sparse data or sparse views and
real-time simulation of biophysical properties. The papers were divided into two general topics
named simulation based approaches for medical imaging and synthesis and its applications in
computational medical imaging.
