EAN: 9783319503516

ALTERNATIVES FOR DERMAL TOXICITY TESTING GEBUNDEN

This book provides comprehensive information on the alternative (non-animal) dermal toxicity
test methods currently available for industrial  regulatory  and academic use and also explores
potential future developments. It encompasses all areas of dermal toxicity  including skin
irritation  skin corrosion  skin sensitization  UV-induced effects  and skin genotoxicity. An
individual chapter is devoted to each test method  with coverage of the scientific basis 
validation status and regulatory acceptance  applications and limitations  available protocols
and potential role within testing strategies. In addition  perspectives from the test developer
are presented  for example regarding critical steps in the protocol. The closing section
addresses areas that may be of relevance for the future of dermal toxicity safety testing 
including the validation and regulatory acceptance of integrated testing strategies  novel
complex skin models  and high-throughput screening techniques.

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