This book presents the latest advances concerning the regulation of chromosome segregation
during cell division by means of centromeres and kinetochores. The authors cover both
state-of-the-art techniques and a range of species and model systems shedding new light on the
molecular mechanisms controlling the transmission of genetic material between cell divisions
and from parent to offspring. The chapters cover five major areas related to the current study
of centromeres and kinetochores: 1) their genetic and epigenetic features 2) key breakthroughs
at the molecular proteomic imaging and biochemical level 3) the constitutive centromere
proteins 4) the role of centromere proteins in the physical process of chromosome segregation
and its careful orchestration through elaborate regulation and 5) intersections with
reproductive biology human health and disease as well as chromosome evolution. The book
offers an informative and provocative guide for newcomers as well as those already acquainted
with the field.
