Biomedical Applications of Acridines - Jan Jezek Jan Hlavácek Jaroslav Sebestík Gebunden

This book describes applications of acridines for the treatment of various neurodegenerative diseases such as Alzheimer's disease Parkinson's disease and various prion diseases and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore the book presents modern methods of acridine synthesis comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins and due to th eir direct interactions with various enzymes they can be suitable for the treatment of neurodegenerative diseases inflammation immunological disorders and protozoal diseases. The characteristic spectral properties of acridines can be employed in labeling proteins nucleic acids lipids and even cells and their compartments. Moreover they can be applied in photodynamic therapy.