This practical manual written by well-known experts reviews current indications for the use
of IgG concentrates and some other modern immunomodulators and provides fundamental information
on present-day immunomodulation in patients (and mice). The book opens by tracing the
transition from IgG substitution to IgG immunomodulation and providing expert updates on
immunomodulatory indications in autoimmune and inflammatory disorders including hematologic
neurologic dermatologic and other diseases. Basic aspects of IgG concentrates including
methods of production safety currently available products and mechanisms of action are then
discussed. An entire chapter is devoted to the different aspects of immunomodulatory IgG
treatment in the bleeding disorder immune thrombocytopenia (ITP). Finally the transition from
polyclonal to monoclonal antibody (mAb) treatment is addressed in detail covering mAb
development methods mechanisms of action adverse effects and more. Particular attention is
paid to the example of anti-CD20 (B-cell) antibody.
