EAN: 9783319680378

ANTIBODY THERAPY GEBUNDEN

This practical manual  written by well-known experts  reviews current indications for the use
of IgG concentrates and some other modern immunomodulators and provides fundamental information
on present-day immunomodulation in patients (and mice). The book opens by tracing the
transition from IgG substitution to IgG immunomodulation and providing expert updates on
immunomodulatory indications in autoimmune and inflammatory disorders  including hematologic 
neurologic  dermatologic  and other diseases. Basic aspects of IgG concentrates  including
methods of production  safety  currently available products  and mechanisms of action  are then
discussed. An entire chapter is devoted to the different aspects of immunomodulatory IgG
treatment in the bleeding disorder immune thrombocytopenia (ITP). Finally  the transition from
polyclonal to monoclonal antibody (mAb) treatment is addressed in detail  covering mAb
development  methods  mechanisms of action  adverse effects  and more. Particular attention is
paid to the example of anti-CD20 (B-cell) antibody.

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