This book describes recent progress in the development of immunotherapies for advanced sarcoma
paying special attention to the potential role of manipulations of the sarcoma tumor immune
microenvironment in improving patient outcomes. Readers will find a thorough overview of the
state of the art in tumor immunology and immunotherapy as they relate to sarcoma. Among the
topics addressed are advances in vaccine therapy cytokine therapies natural killer cells the
development of adoptive T cell strategies and the scope for use of checkpoint inhibitors in
patients with sarcoma mirroring the tremendous breakthroughs made in other malignancies.
Detailed information is provided on laboratory and clinical research with analysis of outcomes
of recent trials and identification of key challenges. There is every reason to believe that
more effective and less toxic therapies for metastatic sarcoma can be attained by deepening our
understanding of cancer immunology and building on the advances in immunotherapy for other
solid tumors. In this context Immunotherapy of Sarcoma will be of high interest for all
medical oncologists responsible for the treatment of sarcoma patients.
