The synucleinopathy sporadic Parkinson's disease (sPD) is the second most frequent degenerative
disorder of the human nervous system after Alzheimer's disease. The propensity for developing
sPD exists in all ethnic groups worldwide and the prevalence of the disorder increases
considerably with age thereby imposing an enormous social and economic burden on societies
with increased life expectancy. The sPD-associated pathological process is progressive does
not go into remission and can take decades to reach its culmination if it is not be terminated
prematurely by death owing to other causes. Against the background of the normal morphology and
anatomy the authors analyze the pathoanatomy of sPD in the nervous system at various
neuropathological stages and summarize the potential functional consequences of the lesions.
